I decide go with Msys setup which should be straightforward and it is, except how the plugins works. There is no libirrsi.dll or such thing so how it could load dll? note that the plugins isn't loadable module, it does depends/linked to Irssi (which has to be irssi.exe itself in windows unless it linked to irssi wholly). I learned about C Perl embedding too from this which involved joining dynaloader.o file in final linking.
|irssi + twirssi in action|
BTW installing twirssi on vanilla msys-perl can be troublesome, there are dozens of modules from CPAN will be installed/updated which in the end still not completely satisfy its dependencies. Careful